Inclusion Body Myositis Causes

Inclusion body myositis is found in more men than women with onset generally occurring after age 50. A small number of IBM cases may be hereditary but most are "sporadic" meaning there is not a direct hereditary link. In most cases, Inclusion body myositis progresses slowly over months or years. There is currently no effective Inclusion Body Myositis Treatment, although current gene therapy trials supported by TMA show promise.

The cause of IBM is unknown. Because of the inflammation associated with Inclusion body Myositis, some doctors think the disease is a form of autoimmune disorder. In this type of disorder, the body’s immune system goes awry and attacks its own tissues in this case, the muscles. Some experts have connected Inclusion body myositis to infection by a virus that has yet to be identified. Other researchers believe that the primary problem in IBM is an age related inability of the muscle to deal with unhelpful chemicals.

There is no successful course of Treatment for Inclusion Body Myositis. The disease is not responsive to corticosteroids and immunosuppressive drugs two drugs that often treat inflammatory or autoimmune conditions. Different evidence suggests that intravenous immunoglobulin may help somewhat in a small number of cases, but the benefit does not last long. Physical therapy may be helpful in maintaining mobility and helping to keep joints movable. Further therapy, including treatments for the swallowing problems, is symptomatic and helpful.