Polycythemia vera is a kind of blood cancer in which the bone marrow produces red blood cells in huge amounts making the blood denser and darker. It also results in excessive production of white blood cells and platelets.
What is Polycythemia Vera?
Polycythemia Vera is a disorder in the bone marrow, which produces a higher volume of red blood cells than the normal production level. This increased production is termed as erythrocytosis. Polycythemia is a group of diseases called myeloproliferative neoplasms.
Polycythaemia vera is a rare chronic disease diagnosed in an estimated 2 to 3 people per 100,000 population. Although it can occur at any age, polycythaemia vera usually affects older people, with most patients diagnosed over the age of 55 years. Polycythaemia vera is rare in children and young adults. It occurs more commonly in males than in females.
Polycythemia Vera impacts barely hundreds of men than girls. The sickness is calculable to have an effect on about two people in step with the 100,000 in the trendy populace. It occurs most regularly in humans at 60 years recent but could have an effect on people of any age. It is very unusual for humans under 20. With most patients diagnosed over the age of 55 years. Polycythaemia vera is rare in children and young adults. It occurs more commonly in males than in females.
Key Facts of Polycythemia Vera
- Polycythemia Vera is also known medically as erythremia, primary polycythemia and polycythemia rubra vera.
- Most commonly found in elderly people.
- Median age for PV was identified as 60 years old.
- It is said to be caused by neoplastic proliferation.
- Enlarged liver or spleen, gouty modules in a physical exam can determine the presence of Polycythemia vera.
- People who do not manage Polycythemia vera are at higher risk of heart attack, stroke and other thrombotic occurences.
- If not tackled in time it can turn fatal.
- Chemotherapy, low does aspirin, phlebotomy and hematocrit are some of the management options for Polycythemia vera.
Causes of Polycythemia Vera
No one knows exactly what Causes of Polycythemia Vera. Evidence suggests that proteins recognized as Janus kinases, or JAKs are involved. JAK proteins send signals that affect the creation of blood cells in the bone marrow. When JAKs send too many signals they cause the bone marrow to make too several blood cells. This is called overactive signaling. Overactive JAK signaling is a key contributor to the development of PV.
The reason behind this genetic effect has not been recognized by the researchers. Therefore the only recognized cause at the moment is:
Too much production of red blood cells by the bone marrow
It's not clear what Causes of Polycythemia Vera the mutations seen in PV. Researchers believe the mutation happens after conception meaning that your mother and father don't have it so it's acquired rather than inherited from a parent.
Symptoms of Polycythemia Vera
There are some keys Symptoms of Polycythemia Vera that make it easier for the health care professionals to identify this disorder before they can go onto beginning the high-end disease management routine. The following are the most common Symptoms of Polycythemia Vera. Though each individual may experience symptoms differently.
The Symptoms of Polycythemia Vera may look like other blood disorders or medical problems. Always consult your doctor for a diagnosis.
Common Symptoms of Polycythemia Vera include:
- Red skin spots
- Vision problems
- Bone pain
- Phlebitis symptoms associated to blood clotting in veins
- Itching mostly after a warm shower
- Sweating at night or during the day
- Blurred vision or blind spots
- Painful burning or numbness of the hands or feet
- Bleeding from the gums and heavy bleeding from small cuts
- Shortness of breath
- Abdominal pain or discomfort
- Early feeling of fullness when eating
- Pain under the left ribs
- Problems concentrating
- Dizziness, vertigo, lightheadedness
- Ringing in the ears
- Reddening of the face, or a burning feeling on the skin
Other Symptoms of Polycythemia Vera include headaches, dizziness, ringing in the ears tinnitus and impaired vision. The skin may moreover become itchy pruritus or reddened erythema. Affected individuals may also have an enlarged spleen splenomegaly and an increased risk for heart disease and there is a small chance that Polycythemia Vera may development to cause leukemia cancer of the blood.
Diagnosis of Polycythemia Vera
Polycythemia Vera may not be cause signs or symptoms for years. The disease commonly is found during routine blood tests done for further reasons. If the results of your blood tests are not normal, your doctor may want to do more tests. Your doctor will Diagnosis of Polycythemia Vera based on your signs and symptoms your age and overall health, your medical history, a physical exam and test results.
During the physical exam your doctor will look for signs of PV. He or she will check for an enlarged irritation red skin on your face and bleeding from your gums.
Some of the same tests used to rule out or diagnose leukemia are also used to Diagnosis of Polycythemia Vera. These tests include:
- Complete blood count to measure the number and quality of white blood cells, red blood cells and platelets
- Blood chemistry tests to check how well certain organs are working
- Reverse transcriptase polymerase chain reaction (RT-PCR) to see if cells in a sample of blood or bone marrow have the JAK2 gene mutation
- Bone marrow aspiration and biopsy to approve whether or not you have Polycythemia Vera
Prognosis of Polycythemia Vera
If you are already coping with one condition that can cause secondary polycythemia, such as COPD or a tumor, learning that you have a second diagnosis to cope with is understandably frustrating. You want to feel better not worse. Your Prognosis of Polycythemia Vera with PV depends largely on whether you get treatment.
- Heart attack
- Deep vein thrombosis
- Pulmonary Embolism: a blood clot in the lung
- Ischemic Stroke: A stroke due to loss of blood supply to the brain
- Myelofibrosis: The advanced stage of PV that scars the bone marrow and can widen the liver and spleen
In the fight against PV information is power. Read to receive news and updates about the latest PV treatment options and other resources to change your Prognosis of Polycythemia Vera.
Risk Factors of Polycythemia Vera
Some of the Risk Factors of Polycythemia Vera include:
- Chronic hypoxia
- Long-term cigarette smoking
- Familial and genetic predisposition
- Living in high altitudes
- Race: Caucasians, Ashkenazi Jews
- Long-term exposure to carbon monoxide tunnel workers, car garage attendants, residents of highly polluted cities
Complications of Polycythemia Vera
The chance of both bleeding and clotting Complications of Polycythemia Vera can be reduced with medicine to lessen blood stickiness and also lower the red blood cell and platelet counts.
The possible Complications of Polycythemia Vera include:
- Rise in the quantity of red blood cells leads to abnormal functioning of other organs for example stomach, small intestine or esophagus
- Other complications connected with Polycythemia Vera include, gout and certain types of leukemia
- Formation of clots due to the accumulation of red blood cells thereby lessening its fluidity. This can lead to a stroke, heart attack or cause a blockage in any of the body arteries
Key Points of Polycythemia Vera
Key Points of Polycythemia Vera include are:
- Polycythemia Vera is blood disorder in which the bone marrow produces too various red blood cells. The extra cells make the blood too thick increasing the risk of blood clots
- Treatment may include venipuncture to remove blood and taking aspirin
- Blood clots may cause grave problems depending on where they form. The clots can reduction the blood supply to the heart, brain, or liver for instance
Prevention of Polycythemia Vera
There are no known Prevention of Polycythemia Vera measures that will lessen your chances of getting primary polycythemia the condition is not contagious.
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- Take 2 tablets each day in the morning after breakfast and evening after dinner.
- Fix times for daily intake and follow precisely.
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Here we have some old school tips compiled for you to take advantage from. We will keep updating them as soon as we come up with something new through experiment. In the meanwhile read and follow these:
- Try to limit foods that enhance the production of red blood cells in the body.
- Wear warm gloves and socks to help you stay safe from cold.
- Drink ample amount of liquids to keep you well hydrated.
- Avoid direct exposure to heat or sunlight.
- Avoid hot baths.
- All these tips will keep you motivated and make you feel good about yourself while you are still undergoing the Polycythemia vera management routine with our Herbal Alternative Medicine.
- These tips and tricks are by no means a replacement of actual products.