Granuloma Annulare Treatment 2015
Granuloma annulare is a noninfectious granulomatous skin condition that can present with a diversity of cutaneous morphologies. It is characterized by collagen degeneration, mucin deposition, and palisaded or interstitial histiocytes. Though the mechanism underlying growth of Granuloma annulare is unknown, studies point to a cell-mediated hypersensitivity reaction to an as-yet undetermined antigen. Systemic relations with diabetes, thyroid disorders, malignancy, lipid abnormalities, and infection are describe in atypical GA. Treatment for Granuloma Annulare is divided into localized skin-directed therapies and systemic immunomodulatory and immunosuppressive therapies. The selected treatment modality should be based on disease severity, comorbid conditions, consideration of possible side effects, and patient preference.
In most cases no treatment is required. If treatment is preferred, it may be helpful to apply a recommendation cortisone cream to the skin. Cortisone can be injected into the lesions themselves if topical fail.
In very widespread or difficult cases, effective treatments are tried. These include Trental and Ultraviolet treatment. Although often successful the Granuloma annulare tends to return finally after they are discontinued. Other treatments irregularly tried when these fail are Dapsone, potassium Iodide and oral steroids.