Waldenstrom's Macroglobulinemia Causes

Waldenstrom's Macroglobulinemia is a malignant disorder of the bone marrow and lymphatic tissues, a kind of lymphoma and characterized by the occurrence of abnormally big numbers of an exacting type of white blood cell known as B lymphocytes. As these cells mount up in the body, too much quantities of an antibody protein known as IgM are created. Large amounts of IgM causes the blood to become thick and affects the flow of blood during the smaller blood vessels, leading to some of the symptoms of the disorder. Small blood vessels may tear leading to bleeding in the nose, gums, or retina.

There is no definitely known Waldenstrom's Macroglobulinemia causes. WM is a result of a condition called lymphoplasmacytic lymphoma. This is a cancer of the white blood cells, in which the B or T immune cells start dividing speedily. The correct cause of also much creation of the IgM antibody is unknown. Production of excess IgM causes the blood to become too thick. This is called hyperviscosity. It can make it harder for blood to flow through small blood vessels.

The Treatment of Waldenstrom's Macroglobulinemia plan is to diminish the symptoms and the risk of developing organ damage. Plasmapheresis removes unnecessary substances from the blood. In Waldenstrom's Macroglobulinemia, it removes or diminishes the high level of IgM. It also quickly controls the symptoms caused by blood thickening. Medication may include corticosteroids, a combination of chemotherapy medicines and the monoclonal antibody to B cells, rituximab.